Comparative evaluation of the pharmacological value of virgin coconut oil, omega 3 fatty acids, and orlistat in experimental study on obesity with normo/hyper-lipidaemic diet

• Published in: PharmaNutrition 2020-09, Vol.13, p.100192, Article 100192
• Main Authors: Adeyemi, Wale Johnson, Olayaki, Luqman Aribidesi, Abdussalam, Tahir Ahmad, Ige, Serah Funke, Okesina, Bidemi Kazeem, Abolarin, Patrick Oluwole, Usman, Hidayah, Tiamiyu, Aishat Oluwatofunmi, Seidu, Maryam Oluremi, Opabode, Abdmukit Olalekan
• Format: Article
• Language: English
• Subjects: Hepatic tissue; Liver; Obesity; Omega 3 fatty acids; Orlistat; Virgin coconut oil
• ISSN: 2213-4344; 2213-4344
• DOI: 10.1016/j.phanu.2020.100192

[Display omitted] •Dietary modification in obese state reversed or increased the adverse effects of the disease.•Orlistat caused hepatic structural alterations in obese state.•Like orlistat, VCO and N-3 showed considerable anti-obesitogenic effects. In this study, we compared the anti-obesitogenic effects of virgin coconut oil (VCO), omega3 fatty acids (N-3), and orlistat in obese Wistar rats fed with normo- or hyper-lipidaemic diets. The eighty rats (n = 10) that were used for this study were divided into 8 groups. The results revealed that VCO, N-3, and orlistat showed comparable effects on lactate dehydrogenase, superoxide dismutase, c-reactive protein, gamma-glutamyltranspeptidase, alkaline phosphatase, aspartate aminotransferase, uric acid, total protein, atherogenic and Lee indices, lipid profile, and insulin resistance. However, VCO demonstrated superior actions than N-3 and orlistat on malondialdehyde, glutathione peroxidase, and interleukin -6, while orlistat and N-3 proved to have a better effect on total antioxidant capacity and alanine aminotransferase respectively. Moreover, VCO and orlistat had an equivalent but more desirable effects than N-3 on glucose and insulin resistance, while VCO and N-3 precipitated a parallel but dominant action than orlistat on total bilirubin. The histological findings largely agreed with the biochemical assays. Conclusively, like orlistat, VCO and N-3 showed considerable anti-obesitogenic effects.