Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies

[Display omitted] Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In t...

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Bibliographic Details
Published in:Pharmacological research 2016-12, Vol.114, p.56-66
Main Authors: Wang, Kui, Kievit, Forrest M., Zhang, Miqin
Format: Article
Language:English
Subjects:
Animals
Cancer gene therapy
Gene delivery
Gene Expression Regulation, Neoplastic
Gene Transfer Techniques
Genetic Therapy - methods
Humans
Immunotherapy - methods
Nanomedicine - methods
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Nanotechnology - methods
Neoplasms - genetics
Neoplasms - therapy
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Summary:[Display omitted] Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In the past decades, gene therapy has undergone remarkable progress, and is now poised to become a first line therapy for cancer. Among various gene delivery systems, nanoparticles have attracted much attention because of their desirable characteristics including low toxicity profiles, well-controlled and high gene delivery efficiency, and multi-functionalities. This review provides an overview on gene therapeutics and gene delivery technologies, and highlight recent advances, challenges and insights into the design and the utility of nanoparticles in gene therapy for cancer treatment.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2016.10.016