Interaction of herbal products with prescribed medications: A systematic review and meta-analysis

[Display omitted] Although several studies on pharmacokinetic and/or pharmacodynamic herb–drug interactions (HDI) have been conducted in healthy volunteers, there is large uncertainty on the validity of these studies. A qualitative review and a meta-analysis were performed to establish the clinical...

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Bibliographic Details
Published in:Pharmacological research 2019-03, Vol.141, p.397-408
Main Authors: Awortwe, Charles, Bruckmueller, Henrike, Cascorbi, Ingolf
Format: Article
Language:English
Subjects:
Animals
Biological Transport - drug effects
Cytochrome P-450 Enzyme System - metabolism
Cytochrome P450
Drug transporters
Echinacea - chemistry
Herb-Drug Interactions
Herbal products
Humans
Hypericum - chemistry
Hypnotics and Sedatives - metabolism
Hypnotics and Sedatives - pharmacokinetics
Midazolam - metabolism
Midazolam - pharmacokinetics
Oximes - metabolism
Oximes - pharmacokinetics
Plant Preparations - chemistry
Plant Preparations - pharmacology
Prescribed medications
Tea - chemistry
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Summary:[Display omitted] Although several studies on pharmacokinetic and/or pharmacodynamic herb–drug interactions (HDI) have been conducted in healthy volunteers, there is large uncertainty on the validity of these studies. A qualitative review and a meta-analysis were performed to establish the clinical evidence of these interaction studies. Out of 4026 screened abstracts, 32 studies were included into the qualitative analysis. The meta-analysis was performed on eleven additional studies. St. John’s wort (SJW) significantly decreased the AUC (p 
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2019.01.028