Quebrachitol-induced gastroprotection against acute gastric lesions: Role of prostaglandins, nitric oxide and K + ATP channels

The effect of Quebrachitol (2- O-methyl- l-inositol), a bioactive component from Magonia glabrata fruit extract was investigated against gastric damage induced by absolute ethanol (96%, 0.2 ml/animal) and indomethacin (30 mg/kg, p.o.), in mice. Quebrachitol at oral doses of 12.5, 25, and 50 mg/kg ma...

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Published in:Phytomedicine (Stuttgart) 2008-05, Vol.15 (5), p.327-333
Main Authors: de Olinda, T.M., Lemos, T.L.G., Machado, L.L., Rao, V.S., Santos, F.A.
Format: Article
Language:English
Subjects:
Animals
Arginine - pharmacology
Capsaicin - analogs & derivatives
Capsaicin - pharmacology
Diazoxide - pharmacology
Dose-Response Relationship, Drug
Ethanol
Ethanol - toxicity
Gastroprotection
Glyburide - pharmacology
Indomethacin - toxicity
Inositol - administration & dosage
Inositol - analogs & derivatives
Inositol - therapeutic use
KATP Channels - physiology
Male
Mice
Misoprostol - pharmacology
Molecular Structure
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide
Nitric Oxide - physiology
Phytotherapy
Potassium channels
Prostaglandins
Prostaglandins - physiology
Quebrachitol
Stomach Ulcer - chemically induced
Stomach Ulcer - prevention & control
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Summary:The effect of Quebrachitol (2- O-methyl- l-inositol), a bioactive component from Magonia glabrata fruit extract was investigated against gastric damage induced by absolute ethanol (96%, 0.2 ml/animal) and indomethacin (30 mg/kg, p.o.), in mice. Quebrachitol at oral doses of 12.5, 25, and 50 mg/kg markedly attenuated the gastric lesions induced by ethanol to the extent of 69%, 64%, and 53% and against indomethacin by 55%, 59%, and 26%, respectively. While pretreatment with TRPV1 antagonist capsazepine (5 mg/kg, i.p.) failed to block effectively the gastroprotective effect of quebrachitol (25 mg/kg) against ethanol damage, the non-selective cyclooxygenase inhibitor indomethacin (10 mg/kg, p.o.), almost abolished it. Furthermore, quebrachitol effect was significantly reduced in mice pretreated with l-NAME, or glibenclamide, the respective inhibitors of nitric oxide synthase and K + ATP channel activation. Thus we provide the first evidence that quebrachitol reduces the gastric damage induced by ethanol and indomethacin, at least in part, by mechanisms that involve endogenous prostaglandins, nitric oxide release, and or the activation of K + ATP channels.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2007.09.002