ent-Abietane diterpenoids from Isodon rubescens var. rubescens

• Published in: Phytochemistry (Oxford) 2007-03, Vol.68 (5), p.616-622
• Main Authors: Huang, Sheng-Xiong, Pu, Jian-Xin, Xiao, Wei-Lie, Li, Li-Mei, Weng, Zhi-Ying, Zhou, Yan, Han, Quan-Bin, Peng, Shu-Lin, Ding, Li-Sheng, Lou, Li-Guang, Sun, Han-Dong
• Format: Article
• Language: English
• Subjects: abietane diterpene; anticarcinogenic activity; Antineoplastic Agents - toxicity; Bioconversions. Hemisynthesis; Biological and medical sciences; Biotechnology; Cell Line, Tumor - drug effects; Cell Survival - drug effects; Chemical constitution; chemical structure; cultured cells; Cytotoxicity; Diterpenes, Abietane - chemistry; Diterpenes, Abietane - isolation & purification; Diterpenes, Abietane - toxicity; Diterpenoid; diterpenoids; ent-Abietane; Fundamental and applied biological sciences. Psychology; Hebeiabinin; Humans; Isodon; Isodon - chemistry; Isodon - toxicity; Isodon rubescens var. rubescens; Labiatae; Lamiaceae; Magnetic Resonance Spectroscopy; Methods. Procedures. Technologies; Models, Molecular; phytochemicals; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Leaves - chemistry; Plant physiology and development; spectral analysis; stereochemistry
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2006.11.007

ent-Abietane diterpenoids, hebeiabinins A–F ( 1– 5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. Structures of 1– 5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cell lines. Compound 5 was the most active with IC 50 value of 0.91 μM against A549 cells. ent-Abietane diterpenoids, hebeiabinins A–F ( 1– 5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1– 5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC 50 value of 0.91 μM against A549 cells.