Bafoudiosbulbins F and G, further clerodane diterpenoids from Dioscorea bulbifera L. var sativa and revised structure of Bafoudiosbulbin B

• Published in: Phytochemistry (Oxford) 2008-09, Vol.69 (12), p.2374-2379
• Main Authors: Teponno, Rémy Bertrand, Tapondjou, Azefack Léon, Abou-Mansour, Eliane, Stoeckli-Evans, H., Tane, Pierre, Barboni, Luciano
• Format: Article
• Language: English
• Subjects: bafoudiosbulbin; Bafoudiosbulbins F–G; Biological and medical sciences; chemical constituents of plants; Chemical constitution; chemical structure; clerodane diterpenes; Clerodane diterpenoids; Dioscorea bulbifera; Dioscorea bulbifera L. var sativa; Dioscorea bulbifera var. sativa; Dioscoreaceae; diterpenoids; Fundamental and applied biological sciences. Psychology; medicinal plants; phytochemicals; Plant physiology and development; spectral analysis; stereochemistry; X-ray diffraction analysis
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2008.06.008

From the bulbils of Dioscorea bulbifera L. var sativa, two clerodane diterpenoids, Bafoudiosbulbins F ( 1) and G ( 2), together with five known compounds: Bafoudiosbulbins A–C, 3,5,4′-trihydroxy-3′-methoxybibenzyl, and kaempferol were isolated . Their structures were established by spectroscopic techniques, including 1H, 13C NMR, NOESY, ROESY, COSY, TOCSY, HSQC, and HMBC. The relative stereochemistry of compounds 1 and 2 was assigned on the basis of X-ray crystallographic diffraction analysis. Furthermore, the structure of Bafoudiosbulbin B was revised using extensive 2D NMR techniques as well as chemical transformation. From the bulbils of Dioscorea bulbifera L. var sativa, two clerodane diterpenoids, Bafoudiosbulbins F ( 1) and G ( 2), together with five known compounds: Bafoudiosbulbins A–C, 3,5,4′-trihydroxy-3′-methoxybibenzyl, and kaempferol were isolated . Their structures were established by spectroscopic techniques, including 1H, 13C NMR, NOESY, ROESY, COSY, TOCSY, HSQC, and HMBC. The relative stereochemistry of compounds 1 and 2 was assigned on the basis of X-ray crystallographic diffraction analysis. Furthermore, the structure of Bafoudiosbulbin B was revised using extensive 2D NMR techniques as well as chemical transformation.