Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb

Four benzophenone derivatives 1–4, a known benzophenone 5 and four known flavonoids were isolated from EtOAc extract of Hypericum thasium. Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds against reactive oxygen species produce...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2009, Vol.70 (2), p.244-249
Main Authors: Demirkiran, Ozlem, Ahmed Mesaik, M., Beynek, Hayrettin, Abbaskhan, Ahmed, Iqbal Choudhary, M.
Format: Article
Language:English
Subjects:
Benzophenone glycosides
Biological and medical sciences
Chemical constitution
Fundamental and applied biological sciences. Psychology
General pharmacology
Guttiferae
Hypericum - chemistry
Hypericum thasium
Inhibition of ROS
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant physiology and development
Reactive oxygen species (ROS)
Reactive Oxygen Species - chemistry
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Summary:Four benzophenone derivatives 1–4, a known benzophenone 5 and four known flavonoids were isolated from EtOAc extract of Hypericum thasium. Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds against reactive oxygen species produced by human polymorphoneutrophils. The phytochemical investigation of the ethyl acetate extract of Hypericum thasium has led to the characterization of four benzophenone derivatives 1–4, a known benzophenone 5 and four known flavonoids, quercetin ( 6), quercitrin ( 7), isoquercetin ( 8), and 3, 8′′-biapigenin ( 9). Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds towards the production of reactive oxygen species (ROS) by human polymorphoneutrophils (PMNs). The assay results showed that benzophenones 1 and 3 are extracellular inhibitors of ROS production, while flavonoids 6, 8, and 9 can modulate intracellular ROS production.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2008.10.006