Bisindole alkaloids from Tabernaemontana corymbosa

Continued study in bioactive monoterpenoid alkaloids led to the isolation of nine undescribed alkaloids, taberyunines A-I, together with 32 known ones from the aerial parts of Tabernaemontana corymbosa Roxb. ex Wall (Apocynaceae). Among the undescribed alkaloids, taberyunines A-G and H-I were assign...

Full description

Saved in:
Bibliographic Details
Published in:Phytochemistry (Oxford) 2018-08, Vol.152, p.125-133
Main Authors: Zhang, Bing-Jie, Lu, Jing-Song, Bao, Mei-Fen, Zhong, Xiu-Hong, Ni, Ling, Wu, Jing, Cai, Xiang-Hai
Format: Article
Language:English
Subjects:
Apocynaceae
Bisindole
Cytotoxicity
Monoterpenoid indole alkaloid
NF-κB signaling pathway
Tabernaemontana corymbosa
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Continued study in bioactive monoterpenoid alkaloids led to the isolation of nine undescribed alkaloids, taberyunines A-I, together with 32 known ones from the aerial parts of Tabernaemontana corymbosa Roxb. ex Wall (Apocynaceae). Among the undescribed alkaloids, taberyunines A-G and H-I were assigned to Aspidosperma-Aspidosperma and Vobasinyl-Ibogan type bisindoles, respectively. Their structures were determined by NMR spectra, MS data and X-ray diffraction. Taberyunine B showed significant cytotoxicity against three cancer cell lines. [Display omitted] •Nine undescribed bisindole alkaloids were isolated from Tabernaemontana corymbosa.•The structures were determined by NMR spectra, MS data and X-ray diffraction.•Furan Aspidosperma dimers showed significant cytotoxicity, which might be related to inhibition of NF-κB signal pathway.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2018.04.020