Hyperforin: A natural lead compound with multiple pharmacological activities

Hypericum perforatum L. (Clusiaceae), commonly known as St. John's wort, has a rich historical background as one of the oldest and most widely studied herbal medicines. Hyperforin is the main antidepressant active ingredient of St. John's wort. In recent years, hyperforin has attached incr...

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Published in:Phytochemistry (Oxford) 2023-02, Vol.206, p.113526, Article 113526
Main Authors: Li, Xin-Xin, Yan, Yu, Zhang, Jia, Ding, Kang, Xia, Cong-Yuan, Pan, Xue-Ge, Shi, Yan-Jing, Xu, Jie-Kun, He, Jun, Zhang, Wei-Ku
Format: Article
Language:English
Subjects:
Antidepressive Agents - chemistry
Antidepressive Agents - pharmacology
Bridged Bicyclo Compounds
Clusiaceae
Detection methods
Hyperforin
Hypericum - chemistry
Hypericum perforatum
Pharmacokinetics
Pharmacological activities
Phloroglucinol - pharmacology
Plant Extracts - chemistry
Plants, Medicinal
Synthesis
Terpenes - pharmacology
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Summary:Hypericum perforatum L. (Clusiaceae), commonly known as St. John's wort, has a rich historical background as one of the oldest and most widely studied herbal medicines. Hyperforin is the main antidepressant active ingredient of St. John's wort. In recent years, hyperforin has attached increasing attention due to its multiple pharmacological activities. In this review, the information on hyperforin was systematically summarized. Hyperforin is considered to be a lead compound with diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes and others. It can be obtained by extraction and synthesis. Further pharmacological studies and more precise detection methods will help develop a value for hyperforin. In addition, structural modification and pharmaceutical preparation technology will be beneficial to promoting the research progress of hyperforin based innovative drugs. Although these works are full of known and unknown challenges, researchers are still expected to make hyperforin play a greater value. [Display omitted] •Hyperforin is the main antidepressant active ingredient of St. John's wort.•Hyperforin is a leading compound with various biological activities.•The research progress of hyperforin is objectively updated and analyzed in this review.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2022.113526