A long chain alkylated α-methylene-γ-butyrolactone from Artabotrys odoratissimus fruit

• Published in: Phytochemistry letters 2009-02, Vol.2 (1), p.22-24
• Main Authors: Bordoloi, Prasanta K., Bhuyan, Purnajyoti D., Boruah, Paran, Bordoloi, Manobjyoti, Rao, Paruchuri G.
• Format: Article
• Language: English
• Subjects: 3-Methylene-4-pentadecyldihydrofuran-2-one; Alternaria tenuissima; Annonaceae; Antifungal; Artabotrys odoratissimus; Chenichampa phool; Solanum khasianum
• ISSN: 1874-3900; 1876-7486
• DOI: 10.1016/j.phytol.2008.10.005

An unusual long chain alkylated α-methylene-γ-butyrolactone was isolated from the juice of ripe fruit of Artabotrys odoratissimus R.Br. Its structure was determined as 3-methylene-4-pentadecyldihydrofuran-2-one by spectroscopic methods. It was found to have good antifungal activity against Alternaria tenuissima Kunze Ex Pers. isolated from solasodine producing plant Solanum khasianum Clarke. Minimum Inhibitory Concentration (MIC) and IC50 for 3-methylene-4-pentadecyldihydrofuran-2-one were found as 300 and 51.37 μg/ml, respectively. The standard captan was found to have an MIC and IC50 of 200 and 35.52 μg/ml, respectively. ▪ As part of our ongoing programme for isolation of bioactive molecules from the flora of the Indo-Burma biodiversity belt, an unusual long chain alkylated α-methylene-γ-butyrolactone was isolated from the juice of ripe fruit of Artabotrys odoratissimus R.Br. Its structure was determined as 3-methylene-4-pentadecyldihydrofuran-2-one by spectroscopic methods. It was found to have good antifungal activity against Alternaria tenuissima Kunze Ex Pers. isolated from solasodine producing plant Solanum khasianum Clarke. Minimum Inhibitory Concentration (MIC) and IC 50 for 3-methylene-4-pentadecyldihydrofuran-2-one were found as 300 and 51.37 μg/ml, respectively. The standard captan was found to have an MIC and IC 50 of 200 and 35.52 μg/ml, respectively.