Antiplasmodial β-hydroxydihydrochalcone from seedpods of Tephrosia elata

A new β-hydroxydihydrochalcone ( 1) was isolated from the seedpods of Tephrosia elata. This compound along with other flavonoids are responsible for the antiplasmodial activity of this plant. From the seedpods of Tephrosia elata, a new β-hydroxydihydrochalcone named ( S)-elatadihydrochalcone was iso...

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Bibliographic Details
Published in:Phytochemistry letters 2009-08, Vol.2 (3), p.99-102
Main Authors: Muiva, Lois M., Yenesew, Abiy, Derese, Solomon, Heydenreich, Matthias, Peter, Martin G., Akala, Hoseah M., Eyase, Fredrick, Waters, Norman C., Mutai, Charles, Keriko, Joseph M., Walsh, Douglas
Format: Article
Language:English
Subjects:
( S)-Elatadihydrochalcone
Antiplasmodial activity
Leguminosae
Seedpods
Tephrosia elata
β-Hydroxydihydrochalcone
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Summary:A new β-hydroxydihydrochalcone ( 1) was isolated from the seedpods of Tephrosia elata. This compound along with other flavonoids are responsible for the antiplasmodial activity of this plant. From the seedpods of Tephrosia elata, a new β-hydroxydihydrochalcone named ( S)-elatadihydrochalcone was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatin methyl ether and deguelin were identified. The structures were determined on the basis of spectroscopic evidence. The crude extract and the flavonoids obtained from the seedpods of this plant showed antiplasmodial activities. The literature NMR data on β-hydroxydihydrochalcones is reviewed and the identity of some of the compounds assigned β-hydroxydihydrochalcone skeleton is questioned.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2009.01.002