Three new geranyl aurones from the leaves of Artocarpus altilis

[Display omitted] ► Three new aurones, altilisin H–J, have been isolated from the leaves of Artocarpus altilis. ► The structures were elucidated on the basis of spectroscopic data. ► These compounds were found to show tyrosinase and α-glucosidase inhibitory activities. From the MeOH extract of the l...

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Bibliographic Details
Published in:Phytochemistry letters 2012-09, Vol.5 (3), p.647-650
Main Authors: Mai, Nguyen Thi Thanh, Hai, Nguyen Xuan, Phu, Dang Hoang, Trong, Phan Nguyen Huu, Nhan, Nguyen Trung
Format: Article
Language:English
Subjects:
alpha-glucosidase
Artocapus altilis
Artocarpus altilis
Aurone
aurones
chemical structure
flavonoids
inhibitory concentration 50
leaf extracts
leaves
methanol
Moraceae
spectral analysis
Tyrosinase inhibition
α-Glucosidase inhibition
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Summary:[Display omitted] ► Three new aurones, altilisin H–J, have been isolated from the leaves of Artocarpus altilis. ► The structures were elucidated on the basis of spectroscopic data. ► These compounds were found to show tyrosinase and α-glucosidase inhibitory activities. From the MeOH extract of the leaves of Artocarpus altilis (Moraceae), three new aurones, altilisin H (1), I (2), and J (3), have been isolated together with two known flavonoids. Their structures were elucidated on the basis of spectroscopic data. All compounds possessed tyrosinase inhibitory activity with IC50 values less than 100μM, while compounds 1–3 displayed potent α-glucosidase inhibitory activity with IC50 values ranging from 4.9 to 5.4μM.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2012.06.014