Two new germacranolides from Elephantopus tomentosus

The structures of tomenphantopin C and tomenphantopin D. [Display omitted] ► Both tomenphantopin C and tomenphantopin D were new compounds. ► All compounds were isolated for the first time from Elephantopus tomentosus. ► Compounds 4 and 6 were isolated for the first time from Elephantopus. ► The com...

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Bibliographic Details
Published in:Phytochemistry letters 2012-12, Vol.5 (4), p.800-803
Main Authors: Mei, Wen-Li, Wang, Bei, Zuo, Wen-Jian, Zhao, You-Xing, Dong, Wen-Hua, Liu, Guo-dao, Dai, Hao-Fu
Format: Article
Language:English
Subjects:
antibacterial properties
cytotoxicity
Elephantopus
Elephantopus tomentosus
nuclear magnetic resonance spectroscopy
Tomenphantopin C
Tomenphantopin D
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Summary:The structures of tomenphantopin C and tomenphantopin D. [Display omitted] ► Both tomenphantopin C and tomenphantopin D were new compounds. ► All compounds were isolated for the first time from Elephantopus tomentosus. ► Compounds 4 and 6 were isolated for the first time from Elephantopus. ► The compounds 2–5 were found to possess cytotoxic activities and antibacterial activities. The bioassay-guided chemical investigation of the whole plant of Elephantopus tomentosus led to the isolation of two new germacranolides, tomenphantopin C (1) and tomenphantopin D (2), together with four known compounds (3–6). Their structures were determined by spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). All compounds were evaluated for cytotoxic and antibacterial activities.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2012.09.005