Alkaloids from Glycosmis cochinchinensis twigs

•New alkaloids from Glycosmis cochinchinensis twigs were isolated and identified.•Ten alkaloids were isolated in total and two are new.•Compound 9 exhibited moderate antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MIC=16μg/mL). A phytochemical investigation of the twi...

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Bibliographic Details
Published in:Phytochemistry letters 2013-08, Vol.6 (3), p.337-339
Main Authors: Sripisut, Tawanun, Phakhodee, Wong, Ritthiwigrom, Thunwadee, Cheenpracha, Sarot, Prawat, Uma, Deachathai, Suwanna, Machan, Theeraphan, Laphookhieo, Surat
Format: Article
Language:English
Subjects:
Alkaloids
Antibacterial activity
antibacterial properties
antibiotic resistance
branches
Glycosmis
Glycosmis cochinchinensis
methicillin
Rutaceae
spectral analysis
spectroscopy
Staphylococcus aureus
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Summary:•New alkaloids from Glycosmis cochinchinensis twigs were isolated and identified.•Ten alkaloids were isolated in total and two are new.•Compound 9 exhibited moderate antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MIC=16μg/mL). A phytochemical investigation of the twigs of Glycosmis cochinchinensis led to the isolation of two new alkaloids, glycosmisacridone (1) and glycosmisindole (2), together with eight known compounds (3–10). Their structures were elucidated by intensive analysis of their spectroscopic data. Compound 9 exhibited moderate antibacterial activity against methicillin-resistant Staphylococcus aureus SK1with an MIC value of 16μg/mL.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2013.03.018