Two new alkaloids from Asparagus stipularis Forssk. roots

•Two new alkaloids were isolated from Asparagus stipularis Forssk. roots.•Spectroscopic techniques were used to elucidate their structures.•X-ray diffraction analysis was used to confirm structural assignment of 2.•Antiproliferative activity against MCF-7 was investigated. Two new alkaloids, aspasti...

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Bibliographic Details
Published in:Phytochemistry letters 2015-06, Vol.12, p.220-223
Main Authors: Galala, Amal A., Ahmad, Kadria F.M., Zaghloul, Mona G., Mansour, El-Sayed S.A.
Format: Article
Language:English
Subjects:
Alkaloids
Asparagaceae
Asparagus stipularis
Cytotoxic activity
MCF-7 cells
X-ray crystallography
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Summary:•Two new alkaloids were isolated from Asparagus stipularis Forssk. roots.•Spectroscopic techniques were used to elucidate their structures.•X-ray diffraction analysis was used to confirm structural assignment of 2.•Antiproliferative activity against MCF-7 was investigated. Two new alkaloids, aspastipuline (1) and 5-hydroxyaspastipuline (2) were isolated from Asparagus stipularis Forssk. roots. Their structures were elucidated by spectroscopic techniques (1D and 2D NMR, HREIMS). The absolute structure of 2 was established by single-crystal X-ray diffraction analysis. Aspastipuline exhibited a moderate antiproliferative activity against the human mammary gland adenocarcinoma cell line MCF-7.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2015.04.004