Oleanane-type triterpenoid saponins from the roots of Polygala aureocauda Dunn

[Display omitted] •6 compounds were isolated from Polygala aureocauda by chromatographic methods.•4 new and 5 known compounds were identified by analyses of NMR and MS spectra.•Cytotoxic effects of compounds towards A549 and MCF7 cancer cells.•Inhibitory effects of compounds on NO overproduction in...

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Bibliographic Details
Published in:Phytochemistry letters 2019-12, Vol.34, p.59-64
Main Authors: Quang, Tran Hong, Yen, Duong Thi Hai, Nhiem, Nguyen Xuan, Tai, Bui Huu, Ngan, Nguyen Thi Thanh, Anh, Hoang Le Tuan, Oh, Hyuncheol, Kiem, Phan Van, Minh, Chau Van
Format: Article
Language:English
Subjects:
Anti-inflammatory
Oleanane triterpenoid saponin
Polygala aureocauda
Polygalaceae
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Summary:[Display omitted] •6 compounds were isolated from Polygala aureocauda by chromatographic methods.•4 new and 5 known compounds were identified by analyses of NMR and MS spectra.•Cytotoxic effects of compounds towards A549 and MCF7 cancer cells.•Inhibitory effects of compounds on NO overproduction in RAW264.7 cells. Polygala aureocauda Dunn. (Polygalaceae) has been widely used in Vietnamese traditional medicine for the treatment of hepatitis, nephritis, sonasthenia, anaemia, back pain, and knee fatigue. Chemical investigation of a methanol extract of P. aureocauda roots resulted in the isolation of four new oleanane triterpenoid saponins (polyaureosides A–D) and two known ones (polygalasaponin XLVIII and arilloside A). Their structures were elucidated by comprehensive spectroscopic methods, including 1D and 2D NMR and mass spectra. Among the isolates, arilloside A showed a modest anti-inflammatory effect through inhibiting NO overproduction in LPS-stimulated RAW264.7 macrophages, with an IC50 value of 47.4 μM.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2019.09.010