Triterpenoid alkaloids from Buxus rugulosa and their cytotoxic activities

[Display omitted] •Eight triterpenoid alkaloids were isolated from Buxus rugulosa;•The structures of four new triterpenoid alkaloids (1–4) were unambiguously determined.•Compound 2 displayed more potent cytotoxic effect than that of the positive control cisplatin in five tumor cell lines. Phytochemi...

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Bibliographic Details
Published in:Phytochemistry letters 2020-04, Vol.36, p.86-90
Main Authors: Wang, Yong-Long, Xiang, Zhi-Nan, Yuan, Yan, Zhou, Jie-Wen, Tian, Luan-Yuan, Chen, Jia-Chun, Wan, Luo-Sheng
Format: Article
Language:English
Subjects:
Buxus
Chemical structure
Cytotoxic activity
Triterpenoid alkaloid
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Summary:[Display omitted] •Eight triterpenoid alkaloids were isolated from Buxus rugulosa;•The structures of four new triterpenoid alkaloids (1–4) were unambiguously determined.•Compound 2 displayed more potent cytotoxic effect than that of the positive control cisplatin in five tumor cell lines. Phytochemical study of the twigs and leaves of Buxus rugulosa resulted in the isolation of eight triterpenoid alkaloids, including four new triterpenoid alkaloids, namely buxruguloids A–D (1–4), together with four known analogues 5–8. The structures of 1–4 were identified by the analysis of NMR and MS spectroscopic data. All the new compounds were assessed in vitro for their cytotoxic activities against five human tumor cell lines (HCT-116, HT-29, A549, MCF-7 and SW480). It turned out that compound 2 exhibited remarkable cytotoxic activities against these five cell lines with IC50 value ranged from 2.5–12.3 μM, respectively.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2020.01.002