Codojavanosides A-C, three new sesquiterpenoid glycosides from the roots of Codonopsis javanica

• Published in: Phytochemistry letters 2020-12, Vol.40, p.166-170
• Main Authors: Phan, Nguyen Huu Toan, Thuan, Nguyen Thi Dieu, Hien, Nguyen Thi Thu, Huyen, Pham Van, Duyen, Nguyen Huu Huong, Hanh, Tran Thi Hong, Cuong, Nguyen Xuan, Quang, Tran Hong, Nam, Nguyen Hoai, Minh, Chau Van
• Format: Article
• Language: English
• Subjects: Campanulaceae; Campanumoea javanica; Codonopsis javanica; Cytotoxic; Sesquiterpenoid
• ISSN: 1874-3900; 1876-7486
• DOI: 10.1016/j.phytol.2020.10.002

[Display omitted] Phytochemical study of the Codonopsis javanica roots led to isolation of 12 secondary metabolites, including three new sesquiterpenoid glycosides, named codojavanosides A-C (1-3) and nine known compounds, (3R,6E,10S)-2,6,10-trimethyl-3-hydroxydodeca-6,11-diene-2,10-diol (4), (E)-2-hexenyl O-β-d-glucopyranoside (5), oct-1-en-3-ol O-α-l-arabinopyranosyl-(1′′→6′)-O-β-d-glucopyranoside (6), (Z)-3-hexenyl O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside (7), tangshenosides I (8) and II (9), tangshenosides V (10) and VI (11), and corchoionoside C (12). Their structures were identified by comprehensive analyses of the 1D and 2D NMR and mass spectra. Evaluation of their cytotoxic effects toward three human cancer cell lines, including lung (A549), liver (HepG2), and breast (MCF7) revealed that compounds 1, 2, 4 and 11 exhibit weak cytotoxicity toward the A549 cell line, with the induction of cell death ranging from 40.8–66.4 % at the concentration of 100 μM.