Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity

[Display omitted] •An undescribed lignan and a phenolic diglycoside have been isolated from Peperomia vulcanica.•Their structures were established by spectroscopy method.•The mixture 10a and 10b exhibited potent antiplasmodial activity (IC50 = 0.35 μg/mL). The investigation of the CH2Cl2-MeOH (1:1)...

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Bibliographic Details
Published in:Phytochemistry letters 2021-02, Vol.41, p.14-20
Main Authors: Chouna, Hardo Suzy Donfack, Bankeu, Jean Jules Kezetas, Fongang, Yannick Stéphane Fotsing, Dize, Darline, Ponou, Beaudelaire Kemvoufo, Bitchagno, Gabin Thierry Mbahbou, Awantu, Angelbert Fusi, Lenta, Bruno Ndjakou, Fekam, Fabrice Boyom, Ngouela, Silvère Augustin, Opatz, Till, Sewald, Norbert
Format: Article
Language:English
Subjects:
Antileishmanial
Antiplasmodial
Peperolignan
Peperomia vulcania
Peperotannin
Piperaceae
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Summary:[Display omitted] •An undescribed lignan and a phenolic diglycoside have been isolated from Peperomia vulcanica.•Their structures were established by spectroscopy method.•The mixture 10a and 10b exhibited potent antiplasmodial activity (IC50 = 0.35 μg/mL). The investigation of the CH2Cl2-MeOH (1:1) extract of Peperomia vulcanica which showed antileishmanial activity during preliminary screening led to the isolation of two previously unknown compounds named peperolignan (1) and peperotannin (2) along with 13 known compounds. Their structures were determined on the basis of their spectroscopic data. The isolated compounds were assessed in vitro for their antileishmanial and antiplasmodial activities against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes and the Plasmodium falciparum chloroquine-sensitive 3D7 strain (Pf3D7), respectively. They were also assessed for their cytotoxicity on Raw 264.7 macrophage cells. The mixture of 4-hydroxy-2-[(3,4-methylenedioxyphenyl)nonanoyl]cyclohexan-1,3-dione and 4-hydroxy-2-[(3,4-methylenedioxyphenyl) undecanoyl] cyclo-hexane-1,3-dione (10a and 10b) exhibited potent antiplasmodial activity (IC50 = 0.35 μg/mL) with selectivity index higher than 10-fold (SI = 63.4) and moderate leishmanicidal activity (IC50 = 12.17 μg/mL) with very low selectivity index (SI = 1.82). The obtained results could provide an extent of validation to the traditional uses of Peperomia vulcanica for the treatment of malaria in endemic areas.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2020.10.010