Vinapraesorediosic acids D and E from the lichen Parmotrema praesorediosum (Nyl.) Hale

[Display omitted] •Two new acids (1, 2) were purified from P. praesorediosum.•Their structures were elucidated by spectroscopic methods.•The cytotoxicity of 1 was evaluated against four human cancer cell lines. One new α,β-unsaturated-γ-lactone acid, named Vinapraesorediosic acid D (1), and one new...

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Bibliographic Details
Published in:Phytochemistry letters 2021-02, Vol.41, p.61-64
Main Authors: Huynh, Bui-Linh-Chi, Pham, Nguyen Kim Tuyen, Nguyen, Tan Phat
Format: Article
Language:English
Subjects:
Parmeliaceae
Parmotrema praesorediosum
Vinapraesorediosic acid D
Vinapraesorediosic acid E
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Summary:[Display omitted] •Two new acids (1, 2) were purified from P. praesorediosum.•Their structures were elucidated by spectroscopic methods.•The cytotoxicity of 1 was evaluated against four human cancer cell lines. One new α,β-unsaturated-γ-lactone acid, named Vinapraesorediosic acid D (1), and one new benzoic acid, Vinapraesorediosic acid E (2), were isolated from the lichen Parmotrema praesorediosum. Their chemical structures were elucidated by extensive IR, CD, HR-ESI-MS, and NMR spectroscopic analysis, and comparison with previously published data. Compound 1 was evaluated for the cytotoxicity against four human cancer cell lines (MCF-7, HeLa, NCI-H460, and HepG2) using SRB assay. As results, 1 exhibited moderate activity against MCF-7.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2020.11.001