Anti-proliferative dimeric indole alkaloids from the roots of Bousigonia mekongensis

[Display omitted] •Two new dimeric indole alkaloids were isolated from Bousigonia mekongensis.•Their ability to inhibit glucose-induced mesanginal cell proliferation activity was evaluated.•Compound 3 showed a noteworthy effect with an IC50 value of 2.6 ± 1.0 μM. Two new eburnamine-aspidospermine ty...

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Bibliographic Details
Published in:Phytochemistry letters 2021-12, Vol.46, p.105-109
Main Authors: Wei, Quan-Hao, Wang, Ya-Lan, Zhang, Jin-Ping, Qi, Zheng-Liang, Wang, Xiao-Jing, Wang, Zhi-Wei
Format: Article
Language:English
Subjects:
Bousigonia mekongensis
Indole alkaloid
Mesanginal cell
Structure elucidation
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Summary:[Display omitted] •Two new dimeric indole alkaloids were isolated from Bousigonia mekongensis.•Their ability to inhibit glucose-induced mesanginal cell proliferation activity was evaluated.•Compound 3 showed a noteworthy effect with an IC50 value of 2.6 ± 1.0 μM. Two new eburnamine-aspidospermine type dimeric indole alkaloids and one known compound (leucophyllidine) were isolated from the roots of Bousigonia mekongensis. Their structures were determined based on NMR, MS, FTIR, and UV spectroscopic data. Their ability to inhibit glucose-induced mesanginal cell proliferation activity was evaluated, and leucophyllidine showed a noteworthy effect with an IC50 value of 2.6 ± 1.0 μM.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2021.10.001