Two new guaiane-sesquiterpenes from the cultured lichen mycobiont of Diorygma pruinosum

Lichens and the mycobionts derived from lichen-source are believed to be a valuable source of bioactive compounds. Diorygma pruinosum is a native lichen in Vietnam. A mycobiont of Diorygma pruinosum was separated, then cultivated. Phytochemical data on this lichen and its cultured mycobionts are sca...

Full description

Saved in:
Bibliographic Details
Published in:Phytochemistry letters 2022-12, Vol.52, p.59-62
Main Authors: Do, Thanh-Hung, Aree, Thammarat, Nguyen, Huu-Hung, Nguyen, Hoang-Chuong, Vo, Thi-Phi Giao, Nguyen, Ngoc-Hong, Duong, Thuc-Huy
Format: Article
Language:English
Subjects:
Cultured lichen mycobiont
Diorygma pruinosum
Guaiane
Pruinosone
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lichens and the mycobionts derived from lichen-source are believed to be a valuable source of bioactive compounds. Diorygma pruinosum is a native lichen in Vietnam. A mycobiont of Diorygma pruinosum was separated, then cultivated. Phytochemical data on this lichen and its cultured mycobionts are scarce. The present study described the isolation and structural elucidation of two new guaiane-type sesquiterpenes, namely pruinosone (1) and hydroxypruinosone (2). Their absolute chemical structures were elucidated by extensive 1D and 2D NMR analysis, high-resolution mass spectroscopy, electronic circular dichroism (ECD), and comparisons in the literatures. Compounds 1 and 2 were evaluated for alpha-glucosidase inhibition and antimicrobial activity. [Display omitted] •Phytochemical data on the cultured mycobiont of Diorygma pruinosum were investigated.•Two new guaiane-type sesquiterpenes namely pruinosone (1) and hydroxypruinosone (2) were isolated.•Compounds were evaluated for alpha-glucosidase inhibition and antimicrobial activity.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2022.09.005