Chemical constituents from the leaves of Cinnamomum camphora and their α-glucosidase inhibitory activities

• Published in: Phytochemistry letters 2023-10, Vol.57, p.101-105
• Main Authors: Jiang, Xing, Zhang, Xi-Han, Li, Yu-Xin, Chen, Kai, Lin, Bin, Lu, Tian-Qi, Yang, Min, Chen, Guang-Tong, Fan, Bo-Yi, Wang, Wen-Li
• Format: Article
• Language: English
• Subjects: Cinnamomum camphora; Coumaroylated flavonol glycoside; Phenylpropanoid glycoside; α-glucosidase inhibitory activity
• ISSN: 1874-3900; 1876-7486
• DOI: 10.1016/j.phytol.2023.07.019

The phytochemical investigation on the n-BuOH fraction of the Cinnamomum camphora extract led to the isolation and identification of 37 secondary metabolites. Among them, compound 1, named as camphodiol A, was a new phenylpropanoid glycoside, while compounds 2-10, 12, 13, 16–25, 27, and 29-37 were firstly isolated from this plant. The isolates were evaluated for their α-glucosidase inhibitory activities, and compounds 9, 12-25, 27 and 29 showed potent activities with IC50 values ranging from 0.26 to 113.87 μM. The molecular docking analysis indicated that compound 22 could bind within the active pocket of the α-glucosidase through the hydrogen bonding and π-π interaction. These results demonstrated that the utilization of C. camphora leaves may have potential beneficial effects for the treatment of diabetes mellitus. [Display omitted] •Chemical investigation on the leaves of C. camphora was performed.•A new phenylpropanoid glycoside, camphodiol A (1), was isolated and identified.•Compounds 9, 12-25, 27, and 29 showed potent α-glucosidase inhibitory activities.•Compound 22 could bind within the active pocket of the α-glucosidase.