A new neo-lignan from culture broth of Phellinus linteus and its dengue virus type-2 inhibition activity

Several species within the genus Phellinus are used as a traditional medicine for various health conditions. A new neo-lignan derivative, phelignan A (1), and a known neo-lignan (2) were isolated from the culture broth of P. linteus. The chemical structures of the isolated compounds were determined...

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Bibliographic Details
Published in:Phytochemistry letters 2024-10, Vol.63, p.43-46
Main Authors: Kim, Young-Hee, Choi, Dae-Cheol, Ki, Dae-Won, Kim, Ji-Yul, Song, Jae-Hyoung, Ko, Hyun-Jeong, Lee, In-Kyoung, Yun, Bong-Sik
Format: Article
Language:English
Subjects:
Dengue virus type-2 inhibition
Hymenochaetaceae
Neo-lignan
Phellinus linteus
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Summary:Several species within the genus Phellinus are used as a traditional medicine for various health conditions. A new neo-lignan derivative, phelignan A (1), and a known neo-lignan (2) were isolated from the culture broth of P. linteus. The chemical structures of the isolated compounds were determined using 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The anti-viral activity of the isolated compounds against dengue virus-2 (DENV-2) was evaluated. Compounds 1 and 2 exhibited anti-viral activity against DENV-2, with IC50 values of 1.45 and 2.15 µM, respectively. [Display omitted] •Two neo-lignans, one of them a newly identified neo-lignan, were isolated from the culture broth of Phellinus linteus.•Their chemical structures were determined using NMR and HR-ESI-MS spectroscopy.•Compounds 1–2 exhibited potent anti-viral activities against DENV-2.
ISSN:1874-3900
DOI:10.1016/j.phytol.2024.08.005