Alkaloids from Dendrobium nobile and their anti-inflammatory activities

To identify anti-inflammatory alkaloids, we investigated the aerial parts of cultivated Dendrobium nobile Lindl. Thirteen alkaloids, including a new one, were isolated from the chloroform extract, and their structures were determined using spectroscopic methods. Bioassays assessed the anti-inflammat...

Full description

Saved in:
Bibliographic Details
Published in:Phytochemistry letters 2025-02, Vol.65, p.1-4
Main Authors: Xu, Zao-Yu, Wang, Chao-Fan, Li, Wen, Fu, Nan, Zhan, Rui
Format: Article
Language:English
Subjects:
Alkaloids
Anti-inflammatory activity
Dendrobium nobile Lindl
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To identify anti-inflammatory alkaloids, we investigated the aerial parts of cultivated Dendrobium nobile Lindl. Thirteen alkaloids, including a new one, were isolated from the chloroform extract, and their structures were determined using spectroscopic methods. Bioassays assessed the anti-inflammatory activities of these isolates. Compounds 1 and 9 demonstrated inhibition of nitric oxide production in LPS-activated RAW264.7 macrophages, with IC50 values of 16.7 μM and 24.4 μM, respectively. [Display omitted] •The aerial part of Dendrobium nobile Lindl. was investigated.•Thirteen alkaloids were isolated, including a new one.•The anti-inflammatory activities of the isolates were tested.•Compounds 1 and 9 showed anti-inflammatory activities with the IC50 values of 16.7 and 24.4 µM, respectively.
ISSN:1874-3900
DOI:10.1016/j.phytol.2024.11.003