Placental Abruption Is More Frequent in Women with the Angiotensinogen Thr235 Mutation

Abstract Objective Obstetrical complications such as preeclampsia, fetal growth restriction, and placental abruption are associated with inadequate placental perfusion. Previous studies have shown that the angiotensinogen (AGT) Thr235 mutation is associated with abnormal remodeling of the uterine sp...

Full description

Saved in:
Bibliographic Details
Published in:Placenta (Eastbourne) 2007-07, Vol.28 (7), p.616-619
Main Authors: Zhang, X.Q, Craven, C, Nelson, L, Varner, M.W, Ward, K.J
Format: Article
Language:English
Subjects:
Abruptio Placentae - genetics
Adult
Amino Acid Substitution
Angiotensinogen
Angiotensinogen - genetics
Base Sequence
Biological and medical sciences
DNA Mutational Analysis
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Gene mutation
Human placenta
Humans
Internal Medicine
Molecular Sequence Data
Mutation
Obstetrics and Gynecology
Placental abruption
Pregnancy
Risk Factors
Threonine - chemistry
Threonine - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objective Obstetrical complications such as preeclampsia, fetal growth restriction, and placental abruption are associated with inadequate placental perfusion. Previous studies have shown that the angiotensinogen (AGT) Thr235 mutation is associated with abnormal remodeling of the uterine spiral arteries and occurs at higher frequencies in preeclampsia. This study was done to evaluate whether the AGT Thr235 mutation increases the risk of placental abruption. Materials and methods We compared 62 placentas from women who had placental abruption with 240 control patients of similar age and ethnicity. DNA was extracted from paraffin blocks from placentas. AGT Met235Thr mutation status was determined by single fluoresceine labeled probe real-time PCR using a LightCycler system. Result AGT genotypes were divided into three groups: MM (homozygous wild), TT (homozygous mutant), and MT (heterozygous). The constituent ratio of AGT genotype in abrupted placentas (MM 14.5%, MT 43.5%, TT 41.9%) was significantly different from in control group (MM42.5%, MT 39.6%, TT 17.9%) ( p < 0.001). AGT mutant allele frequency in placental abruption (0.637) was significantly higher than in the control group (0.377) ( p < 0.001). Conclusion The AGT Thr235 mutation was observed more frequently in placental abruption. AGT Thr235 mutation may be considered a risk factor for placental abruption.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2006.09.011