Loading…
Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions
Neurological and neuropsychiatric disorders affect men and women differently. Multiple sclerosis, Alzheimer’s disease, anxiety disorders, depression, meningiomas and late-onset schizophrenia affect women more frequently than men. By contrast, Parkinson’s disease, autism spectrum condition, attention...
Saved in:
Published in: | Progress in neurobiology 2022-12, Vol.219, p.102353, Article 102353 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c404t-9322240fdfdddb52466457047729b6da16a628edfddf7926bfe1dd0f77ecd5dd3 |
---|---|
cites | cdi_FETCH-LOGICAL-c404t-9322240fdfdddb52466457047729b6da16a628edfddf7926bfe1dd0f77ecd5dd3 |
container_end_page | |
container_issue | |
container_start_page | 102353 |
container_title | Progress in neurobiology |
container_volume | 219 |
creator | Pallier, Patrick N. Ferrara, Maria Romagnolo, Francesca Ferretti, Maria Teresa Soreq, Hermona Cerase, Andrea |
description | Neurological and neuropsychiatric disorders affect men and women differently. Multiple sclerosis, Alzheimer’s disease, anxiety disorders, depression, meningiomas and late-onset schizophrenia affect women more frequently than men. By contrast, Parkinson’s disease, autism spectrum condition, attention-deficit hyperactivity disorder, Tourette’s syndrome, amyotrophic lateral sclerosis and early-onset schizophrenia are more prevalent in men. Women have been historically under-recruited or excluded from clinical trials, and most basic research uses male rodent cells or animals as disease models, rarely studying both sexes and factoring sex as a potential source of variation, resulting in a poor understanding of the underlying biological reasons for sex and gender differences in the development of such diseases. Putative pathophysiological contributors include hormones and epigenetics regulators but additional biological and non-biological influences may be at play. We review here the evidence for the underpinning role of the sex chromosome complement, X chromosome inactivation, and environmental and epigenetic regulators in sex differences in the vulnerability to brain disease. We conclude that there is a pressing need for a better understanding of the genetic, epigenetic and environmental mechanisms sustaining sex differences in such diseases, which is critical for developing a precision medicine approach based on sex-tailored prevention and treatment. |
doi_str_mv | 10.1016/j.pneurobio.2022.102353 |
format | article |
fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1016_j_pneurobio_2022_102353</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0301008222001393</els_id><sourcerecordid>36100191</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-9322240fdfdddb52466457047729b6da16a628edfddf7926bfe1dd0f77ecd5dd3</originalsourceid><addsrcrecordid>eNqFUcuO1DAQtBCIHRZ-AfwDGdp24sxwW414rLQSFzhbjt1mPErsyPaMmJ_iG3E2y145tVRdXVXqIuQDgy0DJj-etnPAc4qDj1sOnFeUi068IBu260XTMbZ7STYggDUAO35D3uR8AgApQLwmN0IyALZnG_LncExxijlOeqQ6WIrh4lMME4ZSERNDSX44Fx9DpiXSjL-p9c5hwmAwUx9oOSK9nMeASQ9-9OW68B7TjfGXN0-6j8Ccr-bodZU0VSXHZDHlT_R-msdKXE1cTItk0jNWW1MdCqZLjbNs35JXTo8Z3z3NW_Lzy-cfh2_Nw_ev94e7h8a00JZmLzjnLTjrrLVDx1sp266Htu_5fpBWM6kl3-Gydv2ey8EhsxZc36OxnbXilvSrrkkx54ROzclPOl0VA7U0oE7quQG1NKDWBurl-_VyPg8T2ue7fy-vhLuVgDX_xWNS2fjlmdYnNEXZ6P9r8hfeuaPY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions</title><source>ScienceDirect Freedom Collection</source><creator>Pallier, Patrick N. ; Ferrara, Maria ; Romagnolo, Francesca ; Ferretti, Maria Teresa ; Soreq, Hermona ; Cerase, Andrea</creator><creatorcontrib>Pallier, Patrick N. ; Ferrara, Maria ; Romagnolo, Francesca ; Ferretti, Maria Teresa ; Soreq, Hermona ; Cerase, Andrea</creatorcontrib><description>Neurological and neuropsychiatric disorders affect men and women differently. Multiple sclerosis, Alzheimer’s disease, anxiety disorders, depression, meningiomas and late-onset schizophrenia affect women more frequently than men. By contrast, Parkinson’s disease, autism spectrum condition, attention-deficit hyperactivity disorder, Tourette’s syndrome, amyotrophic lateral sclerosis and early-onset schizophrenia are more prevalent in men. Women have been historically under-recruited or excluded from clinical trials, and most basic research uses male rodent cells or animals as disease models, rarely studying both sexes and factoring sex as a potential source of variation, resulting in a poor understanding of the underlying biological reasons for sex and gender differences in the development of such diseases. Putative pathophysiological contributors include hormones and epigenetics regulators but additional biological and non-biological influences may be at play. We review here the evidence for the underpinning role of the sex chromosome complement, X chromosome inactivation, and environmental and epigenetic regulators in sex differences in the vulnerability to brain disease. We conclude that there is a pressing need for a better understanding of the genetic, epigenetic and environmental mechanisms sustaining sex differences in such diseases, which is critical for developing a precision medicine approach based on sex-tailored prevention and treatment.</description><identifier>ISSN: 0301-0082</identifier><identifier>EISSN: 1873-5118</identifier><identifier>DOI: 10.1016/j.pneurobio.2022.102353</identifier><identifier>PMID: 36100191</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Autism Spectrum Disorder ; Brain Diseases ; Diet ; Epigenetics ; Female ; Gender medicine ; Hormones ; Inactive X chromosome (Xi) ; Male ; Mental disorders ; Neuroinflammation ; Neuropsychiatric diseases ; Non-coding RNA regulators ; Nutrition ; Precision medicine ; Schizophrenia ; Sex Characteristics ; Sex chromosome complement ; Sex Factors ; Stress ; X chromosome inactivation (XCI)</subject><ispartof>Progress in neurobiology, 2022-12, Vol.219, p.102353, Article 102353</ispartof><rights>2022 The Authors</rights><rights>Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-9322240fdfdddb52466457047729b6da16a628edfddf7926bfe1dd0f77ecd5dd3</citedby><cites>FETCH-LOGICAL-c404t-9322240fdfdddb52466457047729b6da16a628edfddf7926bfe1dd0f77ecd5dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36100191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pallier, Patrick N.</creatorcontrib><creatorcontrib>Ferrara, Maria</creatorcontrib><creatorcontrib>Romagnolo, Francesca</creatorcontrib><creatorcontrib>Ferretti, Maria Teresa</creatorcontrib><creatorcontrib>Soreq, Hermona</creatorcontrib><creatorcontrib>Cerase, Andrea</creatorcontrib><title>Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions</title><title>Progress in neurobiology</title><addtitle>Prog Neurobiol</addtitle><description>Neurological and neuropsychiatric disorders affect men and women differently. Multiple sclerosis, Alzheimer’s disease, anxiety disorders, depression, meningiomas and late-onset schizophrenia affect women more frequently than men. By contrast, Parkinson’s disease, autism spectrum condition, attention-deficit hyperactivity disorder, Tourette’s syndrome, amyotrophic lateral sclerosis and early-onset schizophrenia are more prevalent in men. Women have been historically under-recruited or excluded from clinical trials, and most basic research uses male rodent cells or animals as disease models, rarely studying both sexes and factoring sex as a potential source of variation, resulting in a poor understanding of the underlying biological reasons for sex and gender differences in the development of such diseases. Putative pathophysiological contributors include hormones and epigenetics regulators but additional biological and non-biological influences may be at play. We review here the evidence for the underpinning role of the sex chromosome complement, X chromosome inactivation, and environmental and epigenetic regulators in sex differences in the vulnerability to brain disease. We conclude that there is a pressing need for a better understanding of the genetic, epigenetic and environmental mechanisms sustaining sex differences in such diseases, which is critical for developing a precision medicine approach based on sex-tailored prevention and treatment.</description><subject>Animals</subject><subject>Autism Spectrum Disorder</subject><subject>Brain Diseases</subject><subject>Diet</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Gender medicine</subject><subject>Hormones</subject><subject>Inactive X chromosome (Xi)</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Neuroinflammation</subject><subject>Neuropsychiatric diseases</subject><subject>Non-coding RNA regulators</subject><subject>Nutrition</subject><subject>Precision medicine</subject><subject>Schizophrenia</subject><subject>Sex Characteristics</subject><subject>Sex chromosome complement</subject><subject>Sex Factors</subject><subject>Stress</subject><subject>X chromosome inactivation (XCI)</subject><issn>0301-0082</issn><issn>1873-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFUcuO1DAQtBCIHRZ-AfwDGdp24sxwW414rLQSFzhbjt1mPErsyPaMmJ_iG3E2y145tVRdXVXqIuQDgy0DJj-etnPAc4qDj1sOnFeUi068IBu260XTMbZ7STYggDUAO35D3uR8AgApQLwmN0IyALZnG_LncExxijlOeqQ6WIrh4lMME4ZSERNDSX44Fx9DpiXSjL-p9c5hwmAwUx9oOSK9nMeASQ9-9OW68B7TjfGXN0-6j8Ccr-bodZU0VSXHZDHlT_R-msdKXE1cTItk0jNWW1MdCqZLjbNs35JXTo8Z3z3NW_Lzy-cfh2_Nw_ev94e7h8a00JZmLzjnLTjrrLVDx1sp266Htu_5fpBWM6kl3-Gydv2ey8EhsxZc36OxnbXilvSrrkkx54ROzclPOl0VA7U0oE7quQG1NKDWBurl-_VyPg8T2ue7fy-vhLuVgDX_xWNS2fjlmdYnNEXZ6P9r8hfeuaPY</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Pallier, Patrick N.</creator><creator>Ferrara, Maria</creator><creator>Romagnolo, Francesca</creator><creator>Ferretti, Maria Teresa</creator><creator>Soreq, Hermona</creator><creator>Cerase, Andrea</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>202212</creationdate><title>Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions</title><author>Pallier, Patrick N. ; Ferrara, Maria ; Romagnolo, Francesca ; Ferretti, Maria Teresa ; Soreq, Hermona ; Cerase, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-9322240fdfdddb52466457047729b6da16a628edfddf7926bfe1dd0f77ecd5dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Autism Spectrum Disorder</topic><topic>Brain Diseases</topic><topic>Diet</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Gender medicine</topic><topic>Hormones</topic><topic>Inactive X chromosome (Xi)</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Neuroinflammation</topic><topic>Neuropsychiatric diseases</topic><topic>Non-coding RNA regulators</topic><topic>Nutrition</topic><topic>Precision medicine</topic><topic>Schizophrenia</topic><topic>Sex Characteristics</topic><topic>Sex chromosome complement</topic><topic>Sex Factors</topic><topic>Stress</topic><topic>X chromosome inactivation (XCI)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pallier, Patrick N.</creatorcontrib><creatorcontrib>Ferrara, Maria</creatorcontrib><creatorcontrib>Romagnolo, Francesca</creatorcontrib><creatorcontrib>Ferretti, Maria Teresa</creatorcontrib><creatorcontrib>Soreq, Hermona</creatorcontrib><creatorcontrib>Cerase, Andrea</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Progress in neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pallier, Patrick N.</au><au>Ferrara, Maria</au><au>Romagnolo, Francesca</au><au>Ferretti, Maria Teresa</au><au>Soreq, Hermona</au><au>Cerase, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions</atitle><jtitle>Progress in neurobiology</jtitle><addtitle>Prog Neurobiol</addtitle><date>2022-12</date><risdate>2022</risdate><volume>219</volume><spage>102353</spage><pages>102353-</pages><artnum>102353</artnum><issn>0301-0082</issn><eissn>1873-5118</eissn><abstract>Neurological and neuropsychiatric disorders affect men and women differently. Multiple sclerosis, Alzheimer’s disease, anxiety disorders, depression, meningiomas and late-onset schizophrenia affect women more frequently than men. By contrast, Parkinson’s disease, autism spectrum condition, attention-deficit hyperactivity disorder, Tourette’s syndrome, amyotrophic lateral sclerosis and early-onset schizophrenia are more prevalent in men. Women have been historically under-recruited or excluded from clinical trials, and most basic research uses male rodent cells or animals as disease models, rarely studying both sexes and factoring sex as a potential source of variation, resulting in a poor understanding of the underlying biological reasons for sex and gender differences in the development of such diseases. Putative pathophysiological contributors include hormones and epigenetics regulators but additional biological and non-biological influences may be at play. We review here the evidence for the underpinning role of the sex chromosome complement, X chromosome inactivation, and environmental and epigenetic regulators in sex differences in the vulnerability to brain disease. We conclude that there is a pressing need for a better understanding of the genetic, epigenetic and environmental mechanisms sustaining sex differences in such diseases, which is critical for developing a precision medicine approach based on sex-tailored prevention and treatment.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36100191</pmid><doi>10.1016/j.pneurobio.2022.102353</doi><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0301-0082 |
ispartof | Progress in neurobiology, 2022-12, Vol.219, p.102353, Article 102353 |
issn | 0301-0082 1873-5118 |
language | eng |
recordid | cdi_crossref_primary_10_1016_j_pneurobio_2022_102353 |
source | ScienceDirect Freedom Collection |
subjects | Animals Autism Spectrum Disorder Brain Diseases Diet Epigenetics Female Gender medicine Hormones Inactive X chromosome (Xi) Male Mental disorders Neuroinflammation Neuropsychiatric diseases Non-coding RNA regulators Nutrition Precision medicine Schizophrenia Sex Characteristics Sex chromosome complement Sex Factors Stress X chromosome inactivation (XCI) |
title | Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T06%3A49%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chromosomal%20and%20environmental%20contributions%20to%20sex%20differences%20in%20the%20vulnerability%20to%20neurological%20and%20neuropsychiatric%20disorders:%20Implications%20for%20therapeutic%20interventions&rft.jtitle=Progress%20in%20neurobiology&rft.au=Pallier,%20Patrick%20N.&rft.date=2022-12&rft.volume=219&rft.spage=102353&rft.pages=102353-&rft.artnum=102353&rft.issn=0301-0082&rft.eissn=1873-5118&rft_id=info:doi/10.1016/j.pneurobio.2022.102353&rft_dat=%3Cpubmed_cross%3E36100191%3C/pubmed_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c404t-9322240fdfdddb52466457047729b6da16a628edfddf7926bfe1dd0f77ecd5dd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/36100191&rfr_iscdi=true |