Physical characterization and biological studies of a (streptidine)(Pt IICl 4) compound

The physical characterization with spectroscopy and EXAFS, and biological activity studies of a cationic streptidine complex with platinum are reported. The synthesis, characterization and biological properties of a novel platinum compound, (H 2Std)PtCl 4(H 2O) x ( 1, where x = 1–4; H 2Std stands fo...

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Bibliographic Details
Published in:Polyhedron 2009-11, Vol.28 (16), p.3459-3466
Main Authors: Aliaga-Alcalde, Núria, George, Serena DeBeer, Alfaro-Fuentes, Israel, Cooper, Geoffrey J.T., Barba-Behrens, Norah, Bernès, Sylvain, Reedijk, Jan
Format: Article
Language:English
Subjects:
Antimicrobial studies
Cytotoxic assays
Fluorescence studies
Platinum compound
Streptidine
XAS
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Summary:The physical characterization with spectroscopy and EXAFS, and biological activity studies of a cationic streptidine complex with platinum are reported. The synthesis, characterization and biological properties of a novel platinum compound, (H 2Std)PtCl 4(H 2O) x ( 1, where x = 1–4; H 2Std stands for streptidine, the cationic sugar component of streptomycin), are reported in the solid state and in solution. Reaction of streptidine sulfate ((H 2Std)SO 4) with K 2PtCl 4, yields the sparingly soluble hydrated compound (H 2Std)PtCl 4. Structural information has been attained by a variety of spectroscopic techniques, as well as by using Pt L 3- and Cl K-edge X-ray absorption spectroscopy (XAS). The analyses of the data were completed by performing extended X-ray structural characterization of the free ligand as streptidine sulfate, which was found crucial to interpret the nature and structural arrangement of complex 1. In addition, this work also presents the biological activity of complex 1, i.e. cytotoxic assays, antimicrobial studies, DNA titration and fluorescence in vitro experiments. The studies presented in this paper contribute to our understanding of the synergy between platinum and pharmaceutically relevant compounds.
ISSN:0277-5387
DOI:10.1016/j.poly.2009.07.022