Binuclear zinc(II) complexes with the anti-inflammatory compounds salicylaldehyde semicarbazone and salicylaldehyde-4-chlorobenzoyl hydrazone (H 2LASSBio-1064)

• Published in: Polyhedron 2011-06, Vol.30 (11), p.1891-1898
• Main Authors: Parrilha, Gabrieli L., Vieira, Rafael P., Rebolledo, Anayive P., Mendes, Isolda C., Lima, Lidia M., Barreiro, Eliezer J., Piro, Oscar E., Castellano, Eduardo E., Beraldo, Heloisa
• Format: Article
• Language: English
• Subjects: Binuclear Zn(II) complexes; Crystal structures; Hydrazones; Semicarbazones
• ISSN: 0277-5387
• DOI: 10.1016/j.poly.2011.04.024

[Zn 2(HL 1) 2(CH 3COO) 2] ( 1) and [Zn 2(L 2) 2] ( 2) were obtained with salicylaldehyde semicarbazone (H 2L 1) and salicylaldehyde 4-chlorobenzoyl hydrazone (H 2L 2). Crystal structures of ( 1) and [Zn 2(L 2) 2(H 2O) 2]·[Zn 2(L 2) 2(DMSO) 4] ( 3a), obtained by recrystallization of [Zn 2(HL 2) 2(Cl) 2] ( 3), were determined. [Display omitted] ► [Zn 2(HL 1) 2(CH 3COO) 2] was obtained with salicylaldehyde semicarbazone (H 2L 1). ► Zn 2(L 2) 2 was obtained with salicylaldehyde 4-chlorobenzoyl hydrazone (H 2L 2). ► The crystal structure of [Zn 2(L 2) 2(H 2O) 2]·[Zn 2(L 2) 2(DMSO) 4] was determined. ► Complexes are phenoxo-bridged core dimers. ► Coordination of DMSO or water to the zinc center results in release of a co-ligand. Complexes [Zn 2(HL 1) 2(CH 3COO) 2] ( 1) and [Zn 2(L 2) 2] ( 2) were synthesized with salicylaldehyde semicarbazone (H 2L 1) and salicylaldehyde-4-chlorobenzoyl hydrazone (H 2LASSBio-1064, H 2L 2), respectively. The crystal structure of ( 1) was determined. Upon recrystallization of previously prepared [Zn 2(HL 2) 2(Cl) 2] ( 3) in 1:9 DMSO:acetone crystals of [Zn 2(L 2) 2(H 2O) 2]·[Zn 2(L 2) 2(DMSO) 4] ( 3a) were obtained. The crystal structure of 3a was also determined. All crystal structures revealed the presence of phenoxo-bridged binuclear zinc(II) complexes.