Synthesis, characterization, cytotoxicity and antimicrobial studies on Bi(III) dithiocarbamate complexes containing furfuryl group and their use for the preparation of Bi2O3 nanoparticles

• Published in: Polyhedron 2017-01, Vol.121, p.70-79
• Main Authors: Tamilvanan, Sundaramoorthy, Gurumoorthy, Govindasamy, Thirumaran, Subbiah, Ciattini, Samuele
• Format: Article
• Language: English
• Subjects: Antimicrobial; Bismuth oxide nanoparticles; Bismuth(III) dithiocarbamates; Cytotoxicity; Photodegradation
• ISSN: 0277-5387
• DOI: 10.1016/j.poly.2016.09.038

Three new Bi(III) dithiocarbamates have been prepared and characterized. X-ray structure of 3 shows that Bi is in distorted pentagonal pyramidal environment. Cytotoxic activity against KB(cell) 1–3 with IC50=44, 85 and 40μg/ml, respectively. Thermal decomposition of 3 yielded α-Bi2O3 nanobars. Optical, structural and photocatalytic properties of α-Bi2O3 were evaluated. [Display omitted] Bismuth(III) dithiocarbamate complexes, tris(N-furfuryl-N-propyldithiocarbamato-S,S′)bismuth(III) (1), tris(N-furfuryl-N-butyldithiocarbamato-S,S′)bismuth(III) (2) and tris(N-furfuryl-N-benzyldithiocarbamato-S,S′)bismuth(III) (3), have been prepared and characterized by microanalysis, and spectroscopy (IR and NMR). Structure of 3 has been obtained by single crystal X-ray diffraction. This complex contains distorted pentagonal pyramidal Bi(III) centres which attain an overall distorted pentagonal bipyramidal coordination via long range intermolecular Bi⋯S interactions. DFT quantum mechanical studies of 3 were carried out, supporting the partial double bond character of C–N (thioureide) and C–S bonds in dithiocarbamate ligands. All the compounds have been screened against a panel of microbes viz. Vibrio cholerae, Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Aspergillus niger and Candida albicans. Complexes 1 and 3 were found to have better activity against K. pneumoniae, V. cholerae, A. niger and C. albicans than the complex 2. Complexes 1–3 have been evaluated for their in vitro cytotoxic activity against KB cells. Complexes 1 and 3 showed higher activity than 2. Bi2O3 obtained from thermal decomposition of 3 has been characterized by PXRD, HRTEM, EDAX, UV–Vis and Fluorescence spectroscopy. PXRD study showed that the sample is composed of monoclinic phase of α-Bi2O3. Photocatalytic activity of as-prepared α-Bi2O3 was determined by decolourization of rhodamine-B in aqueous solution under ultra violet irradiation.