Synthesis, characterization and phosphatase inhibitory activity of dioxidovanadium(V) complexes with Schiff base ligands derived from pyridoxal and resorcinol

Two structurally characterized dioxidovanadium(V) complexes of ligands obtained by condensation of dihydrazide/hydrazides and pyridoxal/resorcinol were tested for inhibition of tyrosine phosphatase. [Display omitted] In this manuscript, we report the synthesis of dioxidovanadium(V) complexes, their...

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Bibliographic Details
Published in:Polyhedron 2017-07, Vol.130, p.184-194
Main Authors: Siqueira, Josieli D., Menegatti, Angela C.O., Terenzi, Hernán, Pereira, Mateus B., Roman, Daiane, Rosso, Eduardo F., Piquini, Paulo C., Iglesias, Bernardo A., Back, Davi F.
Format: Article
Language:English
Subjects:
dihydrazide/hydrazide
dioxidovanadium(V)
Protein tyrosine phosphatase
Pyridoxal-Schiff bases
Resorcinol
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Summary:Two structurally characterized dioxidovanadium(V) complexes of ligands obtained by condensation of dihydrazide/hydrazides and pyridoxal/resorcinol were tested for inhibition of tyrosine phosphatase. [Display omitted] In this manuscript, we report the synthesis of dioxidovanadium(V) complexes, their identification by spectroscopic and electrochemical methods, the structural characterization by X-ray diffraction and density functional theory calculations, as well as their in vitro inhibitory activity of protein tyrosine phosphatases (PTPs). The structural analysis revealed the formation of dianionic complexes with [VO2]2+ species in compounds 1 and 2. The molecular frontier orbitals of dioxidovanadium(V) complexes are characterized and compared. Furthermore, the enzymatic experiments revealed that complex 1 inhibited at least two of the PTPs evaluated with potent activity (IC50=1.5μM).
ISSN:0277-5387
DOI:10.1016/j.poly.2017.04.004