Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications

A neutral octahedral mononuclear iron tetrabromide complex that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised and exhibits anti biofilm properties well below cytotoxic levels. [Display omitted] •Novel Iron Tetrabromide complex with unusual st...

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Bibliographic Details
Published in:Polyhedron 2020-11, Vol.190, p.114755, Article 114755
Main Authors: Abedin, Nusrat, Alshehri, Abdullah Hamed A., Almughrbi, Ali M.A., Moore, Olivia, Alyza, Sheikh, Rusbridge, Elizabeth K., Masood, Naqash, Egbowon, Biola F., Hargreaves, Alan J., Dafhnis-Calas, Felix, Fitzpatrick, Anthony J.
Format: Article
Language:English
Subjects:
Biofilms
Coordination chemistry
Crystallography
Halides
Iron
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Summary:A neutral octahedral mononuclear iron tetrabromide complex that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised and exhibits anti biofilm properties well below cytotoxic levels. [Display omitted] •Novel Iron Tetrabromide complex with unusual structure.•Three-dimensional supramolecular architecture.•Anti-biofilm properties with respect to inhibition of formation and disintegration of preformed films. A neutral octahedral mononuclear iron(II) tetrabromide complex, [Fe(HAmpy)2Br4], that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised through redox chemistry and analysed using X-ray crystallography. The iron(II) oxidation state is balanced by the protonated pyrazinium nitrogen just outside the coordination sphere. The biological properties of this and two other related complexes are investigated using both Gram-negative and Gram-positive bacteria as well as methicillin resistant strains. They all exhibit some antimicrobial properties albeit at moderate to poor concentrations. However, the tetrahalide complexes analysed exhibit excellent anti-biofilm properties well below cytotoxic levels.
ISSN:0277-5387
DOI:10.1016/j.poly.2020.114755