The pharmacological profile of metal complexes with bis(thiosemicarbazones) and bis(hydrazone)-derived ligands

The work reports the pharmacological applications of non-radioactive metal complexes with bis(thiosemicarbazones) and bis(hydrazone)-derived ligands. The antimicrobial, antiparasitic, and antineoplastic effects of these complexes, together with investigations into the interactions of some complexes...

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Bibliographic Details
Published in:Polyhedron 2024-07, Vol.256, p.116993, Article 116993
Main Authors: Aguirre, Andrea R., Beraldo, Heloisa
Format: Article
Language:English
Subjects:
Bioactivities
Biological targets
Bis(hydrazone)-derived
Bis(thiosemicarbazones)
Metal complexes
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Summary:The work reports the pharmacological applications of non-radioactive metal complexes with bis(thiosemicarbazones) and bis(hydrazone)-derived ligands. The antimicrobial, antiparasitic, and antineoplastic effects of these complexes, together with investigations into the interactions of some complexes with biological targets aiming at understanding their modes of action are described. The potential applications of copper(II) complexes with bis(thiosemicarbazones) for treating neurodegenerative diseases and studies on their mechanisms of action are also discussed. [Display omitted] The present work describes the multiple pharmacological applications of non-radioactive metal complexes with bis(thiosemicarbazones) and bis(hydrazone)-derived Schiff base ligands. The antimicrobial, antiparasitic, and antineoplastic effects of these complexes, together with investigations into the interactions of some complexes with biological targets aiming at understanding their modes of action are described. The potential applications of copper(II) complexes with bis(thiosemicarbazones) for treating neurodegenerative diseases and studies on their mechanisms of action are also discussed.
ISSN:0277-5387
DOI:10.1016/j.poly.2024.116993