Polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications

Oppositely charged polyelectrolytes can be used to form various types of self-assembled structures directed by multivalent ionic interactions. The supramolecular architectures that result are often referred to as polyion complexes (PICs). Synthetic polyion complexes are exciting candidates for biome...

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Bibliographic Details
Published in:Polymer (Guilford) 2014-01, Vol.55 (2), p.453-464
Main Authors: Yoon, Hongsik, Dell, Emma J., Freyer, Jessica L., Campos, Luis M., Jang, Woo-Dong
Format: Article
Language:English
Subjects:
Application fields
Applied sciences
Biological and medical sciences
Capsule
Exact sciences and technology
General pharmacology
Layer-by-layer
Medical sciences
Micelle
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyelectrolyte
Polyion complex
Polymer industry, paints, wood
Self-assembly
Technology of polymers
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Summary:Oppositely charged polyelectrolytes can be used to form various types of self-assembled structures directed by multivalent ionic interactions. The supramolecular architectures that result are often referred to as polyion complexes (PICs). Synthetic polyion complexes are exciting candidates for biomedical applications. Their self-assembly capabilities give rise to hierarchical mesoscopic platforms such as micelles, membranes, and capsules through simple mixing processes. These complexes are also ideal candidates for the transport and delivery of biological agents since biomolecules, such as DNA and proteins can be easily incorporated through ionic interactions. PICs have therefore found use in drug delivery, diagnostics, gene therapy, biosensors and microreactors. In this paper, we briefly review examples of polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications. [Display omitted]
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2013.12.038