Design of spherical agglomerates via crystallization with a non-toxic bridging liquid: From mechanism to application

• Published in: Powder technology 2022-08, Vol.408, p.117725, Article 117725
• Main Authors: Guo, Shilin, Feng, Shanshan, Yu, Changyou, Liu, Yanbo, Li, Kangli, Chen, Mingyang, Han, Dandan, Gong, Junbo
• Format: Article
• Language: English
• Subjects: Crystallization; No biohazardous solvents; Oleic acid; Spherical agglomeration; Wetting performance
• ISSN: 0032-5910; 1873-328X
• DOI: 10.1016/j.powtec.2022.117725

The cooling crystallization-spherical agglomeration (CCSA) technology proposed in this work overcomes the disadvantages of complex process and biohazardous solvents, which has broad application prospects in green and efficient granulation. CCSA selects oleic acid as a novel green and effective bridging liquid, and the results of droplet experiment and molecular simulation indicate that oleic acid presents the best wetting performance compared with the reported bridging liquids. Mechanistic studies demonstrate that oleic acid can induce spherical agglomeration during crystallization in a single solvent system, especially in water, reducing the dosage of organic solvent by about 90%, and fundamentally eliminating the toxicity of bridging liquid. The volume ratio of bridging liquid to solvent (RBS) and agitation are emphasized as the critical parameters tuning the particle size and sphericity. Further, the spherical agglomerates of benzoic acid, L-leucine and aspirin with controllable size and high sphericity were successfully prepared, which verifies the universality of CCSA. [Display omitted] •A green and efficient spherical crystallization technology (CCSA) was designed.•CCSA overcomes the disadvantages of complex process and biohazardous solvents.•A sharp decrease of about 90% of organic solvents, toxicity is eliminated.•The novel bridging liquid oleic acid was developed with wide application range.•Spherical agglomerates of benzoic acid, L-leucine and aspirin were prepared.