The effect of folic acid throughout pregnancy among pregnant women at high risk of pre-eclampsia: A randomized clinical trial

•The plasma Hcy and FA levels are significantly higher in the HD group.•The incidence of PE is reduced in the HD group with compliance >50%.•A high dosage of FA supplement reduces the recurrent PE. Pre-eclampsia is a serious hypertension disease that occurs during pregnancy. Folic acid (FA) suppl...

Full description

Saved in:
Bibliographic Details
Published in:Pregnancy hypertension 2020-01, Vol.19, p.253-258
Main Authors: Zheng, Lili, Huang, Jing, Kong, Hongfang, Wang, Fang, Su, Yuan, Xin, Hong
Format: Article
Language:English
Subjects:
Adult
Apgar Score
Dose-Response Relationship, Drug
Female
Folic acid (FA)
Folic Acid - administration & dosage
Folic Acid - blood
Homocysteine (homocysteine)
Homocysteine - blood
Humans
Hypertension, Pregnancy-Induced - epidemiology
Hypertension, Pregnancy-Induced - prevention & control
Infant, Newborn
Pre-eclampsia
Pre-Eclampsia - epidemiology
Pre-Eclampsia - prevention & control
Pregnancy
Primary and secondary outcomes
Randomized clinical trial
Secondary Prevention
Vitamin B Complex - administration & dosage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•The plasma Hcy and FA levels are significantly higher in the HD group.•The incidence of PE is reduced in the HD group with compliance >50%.•A high dosage of FA supplement reduces the recurrent PE. Pre-eclampsia is a serious hypertension disease that occurs during pregnancy. Folic acid (FA) supplementation has been reported to reduce pre-eclampsia risk in pregnant women. Here, we aimed to assess whether treatment of high doses of FA in pregnant women with high pre-eclampsia risk could prevent the onset of pre-eclampsia. We conducted a randomized clinical trial in 1576 women who had pre-eclampsia or eclampsia in their last pregnancy and had a pregnancy plan. Subjects were randomized into two groups. The low dose (LD) group (n = 788) received 0.4 mg of FA daily from the first 3 months of pregnancy until the entire pregnancy, and the high dose (HD) group (n = 788) received 4 mg of FA per day. We followed up the subjects until production. The plasma homocysteine (homocysteine) and FA levels were significantly higher in the HD group that in the LD group. Severe gestational hypertension, early onset pre-eclampsia (
ISSN:2210-7789
2210-7797
DOI:10.1016/j.preghy.2020.01.005