Effect of Butyric Acid on p53 Expression and Apoptosis in Colon Epithelial Cells in Mice after Treated with 9,10-dimethyl-1,2-benz(a)anthracene

As the most common cancer, colorectal cancer is the fourth leading cause of death among this malignancy disease. Surgery procedure with chemotherapy and radiotherapy for colorectal cancer treatment may cause unpleasant side effects. Therefore, prevention and early detection of the disease is importa...

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Bibliographic Details
Published in:Procedia chemistry 2016, Vol.18, p.141-146
Main Authors: Siregar, Cherry, Wasito, Eddy Bagus, Sudiana, I Ketut
Format: Article
Language:English
Subjects:
butyrate
DMBA
p53 mutan inhibition
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Summary:As the most common cancer, colorectal cancer is the fourth leading cause of death among this malignancy disease. Surgery procedure with chemotherapy and radiotherapy for colorectal cancer treatment may cause unpleasant side effects. Therefore, prevention and early detection of the disease is important. Butyrate, a short chain fatty acid, has a protective effect against colon cancer by inhibiting cell proliferation and inducing apoptosis. We conduct a research to investigate the effect of butyrate as a possible agent to decreased mutant p53 gene expression.
ISSN:1876-6196
1876-6196
DOI:10.1016/j.proche.2016.01.022