Polycaprolactone/Pluronic F127 Tissue Engineering Scaffolds via Electrohydrodynamic Jetting for Gastro Intestinal Repair

Biocompatible tissue engineering (TE) scaffolds were used to closure the leakage area in gastro intestinal (GI) tract as patches; they could induce the regeneration of defected tissue and degraded steadily. However, some disadvantages, such as small and uncontrolled pore size, hinder the application...

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Bibliographic Details
Published in:Procedia CIRP 2017, Vol.65, p.184-188
Main Authors: Wu, Bin, Wu, Yang, Lu, Wen Feng, Fuh, Jerry Y.H.
Format: Article
Language:English
Subjects:
Electro-hydrodynamic jetting
gastro intestinal
Pluronic F127
Polycaprolactone
tissue engineering scaffold
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Summary:Biocompatible tissue engineering (TE) scaffolds were used to closure the leakage area in gastro intestinal (GI) tract as patches; they could induce the regeneration of defected tissue and degraded steadily. However, some disadvantages, such as small and uncontrolled pore size, hinder the application of existed TE scaffolds. In this study, PCL/F127 composite scaffolds were fabricated through electrohydrodynamic jetting (E-jetting) technique. And the E-jetted scaffolds were cultured with esophageal fibroblast cells (the most important cell type in wound healing process) to evaluate their biocompatibility. The results show that E-jetted PCL/F127 scaffold has potential to be an alternative GI tract regeneration tool.
ISSN:2212-8271
2212-8271
DOI:10.1016/j.procir.2017.04.045