Sensitivity Analysis of Bacterial Chemotaxis Models

Chemotaxis is the process, by which cells sense changes in their chemical environment and move towards more favorable conditions. This process is controlled by signaling pathways, which are relatively simple, but bear several important features of the ones of higher organisms. Sensitivity analysis o...

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Bibliographic Details
Published in:Procedia computer science 2011, Vol.7, p.233-234
Main Authors: Danis, Judit, Turányi, Tamás
Format: Article
Language:English
Subjects:
chemotaxis
computer modeling
model identification
signaling pathways
systems biology
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Summary:Chemotaxis is the process, by which cells sense changes in their chemical environment and move towards more favorable conditions. This process is controlled by signaling pathways, which are relatively simple, but bear several important features of the ones of higher organisms. Sensitivity analysis of mathematical chemotaxis models of bacteria Escherichia coli and Bacillus subtilis was carried out and the most important parameters of the signal transduction cascades were determined. Global and local similarities of the sensitivity−time functions were found. Groups of parameters were identified in both models and changes of parameters within the same group can compensate each other to produce exactly the same response of the cell. This means that the parameter values in these models are not unique. On the other hand, this feature indicates a novel type of robustness of the signaling pathways.
ISSN:1877-0509
1877-0509
DOI:10.1016/j.procs.2011.09.062