Integration of holographic sensors into microfluidics for the real-time pH sensing of L. casei metabolism

We describe developments in the integration of analyte specific holographic sensors into PDMS-based microfluidic devices for the purpose of continuous, low-impact monitoring of extra-cellular change in micro-bioreactors. Holographic sensors respond to analyte concentration via volume change, which m...

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Bibliographic Details
Published in:Procedia engineering 2010, Vol.5, p.1352-1355
Main Authors: Bell, Laurence L., Seshia, Ashwin A., Davidson, Colin A.B., Lowe, Chris R.
Format: Article
Language:English
Subjects:
Biosensor
Holography
Microfluidics
PDMS
pH sensor
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Summary:We describe developments in the integration of analyte specific holographic sensors into PDMS-based microfluidic devices for the purpose of continuous, low-impact monitoring of extra-cellular change in micro-bioreactors. Holographic sensors respond to analyte concentration via volume change, which makes their reduction in size and integration into spatially confined fluidics difficult. Through design and process modification many of these constraints have been addressed, and a microfluidics-based device capable of real-time monitoring of the pH change caused by Lactobacillus casei fermentation is presented as a general proof-of-concept for a wide array of possible devices.
ISSN:1877-7058
1877-7058
DOI:10.1016/j.proeng.2010.09.365