A Microscopy Technique based on Bio-impedance Sensors

It is proposed a microscopy for cell culture applications based on impedance sensors. The imagined signals are measured with the Electrical Cell-Substrate Spectroscopy (ECIS) technique, by identifying the cell area. The proposed microscopy allows real-time monitoring inside the incubator, reducing t...

Full description

Saved in:
Bibliographic Details
Published in:Procedia engineering 2012, Vol.47, p.1049-1052
Main Authors: Yúfera, A., Huertas, G., Olmo, A.
Format: Article
Language:English
Subjects:
Biometric circuits
ECIS. Cell culture
Electrical Bio-impedance
Microelectrode
Sensory systems
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is proposed a microscopy for cell culture applications based on impedance sensors. The imagined signals are measured with the Electrical Cell-Substrate Spectroscopy (ECIS) technique, by identifying the cell area. The proposed microscopy allows real-time monitoring inside the incubator, reducing the contamination risk by human manipulation. It requires specific circuits for impedance measurements, a two-dimensional sensor array (pixels), and employing electrical models to decode efficiently the measured signals. Analogue Hardware Description Language (AHDL) circuits for cell-microelectrode enables the use of geometrical and technological data into the system design flow. A study case with 8x8 sensor array is reported, illustrating the evolution and power of the proposed image acquisition.
ISSN:1877-7058
1877-7058
DOI:10.1016/j.proeng.2012.09.330