Low Temperature Co-fired Ceramic Package for Lab-on-CMOS Applied in Cell Viability Monitoring

Lab-on-CMOS chips (LOCMOS) are sophisticated miniaturized analysis tools based on integrated circuit (IC) microchips performing various laboratory functions. We have developed a low temperature co-fired ceramic (LTCC) package for a LOCMOS application regarding cytotoxicity assessment of nanomaterial...

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Bibliographic Details
Main Authors: Halonen, Niina, Kilpijärvi, Joni, Sobocinski, Maciej, Datta-Chaudhuri, Timir, Hassinen, Antti, Prakash, Someshekar B., Möller, Peter, Abshire, Pamela, Smela, Elisabeth, Kellokumpu, Sakari, Spetz, Anita Lloyd
Format: Conference Proceeding
Language:English
Subjects:
capacitance sensing
cytotoxicity assesment
electronics packaging
Lab-on-CMOS
low temperature co-fired ceramics
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Summary:Lab-on-CMOS chips (LOCMOS) are sophisticated miniaturized analysis tools based on integrated circuit (IC) microchips performing various laboratory functions. We have developed a low temperature co-fired ceramic (LTCC) package for a LOCMOS application regarding cytotoxicity assessment of nanomaterials. The LTCC packaged capacitance sensor chip is designed for long-term cell viability monitoring during nanoparticle exposure. The introduced LTCC package utilizes the flip chip bonding technique, and it is biocompatible as well as able to withstand the environmental conditions required to maintain mammalian cell culture directly on the surface of a complementary metal oxide semiconductor (CMOS) integrated circuit.
ISSN:1877-7058
1877-7058
DOI:10.1016/j.proeng.2015.08.769