Action of Valeriana jatamansi Jones on the Apoptosis-related Genes Expression in the Anxiety Model of Rat

To observe the apoptosis-related genes expression in the difference groups and the action of Valeriana jatamansi Jones. EPM was used to make the anxiety model of rat. The gene expression difference chart of apoptosis-related gene in normal rats, anxiety model rats and rats treated by the extract of...

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Bibliographic Details
Published in:Procedia environmental sciences 2011, Vol.8, p.744-750
Main Authors: Zhi-yong, Yan, Tian-e, Zhang, Ling-zhen, Pan, Chang-ying, Zuo
Format: Article
Language:English
Subjects:
Apoptosis-related Gene
gene chip
Valeriana jatamansi Jones
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Summary:To observe the apoptosis-related genes expression in the difference groups and the action of Valeriana jatamansi Jones. EPM was used to make the anxiety model of rat. The gene expression difference chart of apoptosis-related gene in normal rats, anxiety model rats and rats treated by the extract of Valeriana jatamansi Jones were examined by using the gene chip technology. Compared with normal group, the expression of Elk-1, Ets-1, Apaf-1, Bax and Bcl-2 were up-regulated in the model group. But the abnormal gene expression were adjusted in the other groups. The Valeriana jatamansi Jones can play a important role in regulating the abnormal apoptosis-related gene expression in the anxiety model of rat.
ISSN:1878-0296
1878-0296
DOI:10.1016/j.proenv.2011.10.113