Immunohistochemical COX-2 overexpression correlates with HER-2/neu overexpression in invasive breast carcinomas: A pilot study

Cyclooxygenase-2 (COX-2) is a prostaglandin synthase that catalyzes the synthesis of prostaglandin G2 and H2. It has been shown that COX-2 plays an important role in tumorigenesis of different tumor types and it is thought to take part in breast carcinogenesis. In the present study, we aimed to inve...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 2011-03, Vol.207 (3), p.182-187
Main Authors: Çiriş, İbrahim Metin, Bozkurt, Kemal Kürşat, Başpinar, Şirin, Kapucuoğlu, Fatma Nilgün
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Breast cancer
Breast Neoplasms - enzymology
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - enzymology
Carcinoma, Ductal, Breast - pathology
Carcinoma, Intraductal, Noninfiltrating - enzymology
Carcinoma, Intraductal, Noninfiltrating - pathology
Carcinoma, Lobular - enzymology
Carcinoma, Lobular - pathology
Chi-Square Distribution
COX-2
Cyclooxygenase 2 - analysis
Female
HER-2/neu
Humans
Immunohistochemistry
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Paraffin Embedding
Phenotype
Pilot Projects
Receptor, ErbB-2 - analysis
Retrospective Studies
Turkey
Up-Regulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cyclooxygenase-2 (COX-2) is a prostaglandin synthase that catalyzes the synthesis of prostaglandin G2 and H2. It has been shown that COX-2 plays an important role in tumorigenesis of different tumor types and it is thought to take part in breast carcinogenesis. In the present study, we aimed to investigate the relationship of immunohistochemical COX-2 expression with clinicopathological parameters, including HER-2/neu overexpression in invasive breast carcinoma (IBC). Our study population comprised 10 normal breasts, 25 ductal carcinomas in situ (DCIS), and 51 invasive breast carcinomas. Immunohistochemical overexpressions of COX-2 and HER-2/neu were investigated in sections of formalin-fixed, paraffin-embedded blocks by 3 observers. In normal breast, DCIS and IBC, the COX-2 overexpression rate was 0%, 84%, and 58.8%, respectively. In IBC, COX-2 overexpression had a significant relationship with HER-2/neu overexpression (p=0.026) and a high histological grade (p=0.026). COX-2 expression in both DCIS (n=25) and IBC (n=51) was significantly higher than in normal breast tissue (p
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2011.01.005