Single nucleotide polymorphisms and mRNA expression for melatonin MT2 receptor in depression

Abstract Polymorphisms (rs 4753426 and rs 794837) and expression of the melatonin MT2 receptor gene were evaluated in 181 patients with recurrent depressive disorder (rDD) and 149 healthy subjects of Polish origin. We found an increased risk for rDD in patients with the C allele and a decreased risk...

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Published in:Psychiatry research 2011-10, Vol.189 (3), p.472-474
Main Authors: Gałecka, Elżbieta, Szemraj, Janusz, Florkowski, Antoni, Gałecki, Piotr, Bieńkiewicz, Małgorzata, Karbownik-Lewińska, Małgorzata, Lewiński, Andrzej
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Biological and medical sciences
Depression
Medical sciences
Mood disorders
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Abstract Polymorphisms (rs 4753426 and rs 794837) and expression of the melatonin MT2 receptor gene were evaluated in 181 patients with recurrent depressive disorder (rDD) and 149 healthy subjects of Polish origin. We found an increased risk for rDD in patients with the C allele and a decreased risk in patients with the T allele (rs4753426). Patients with the AT heterozygote (rs794837) had an increased mRNA level. The significance of the MT2 receptor gene and the risk of rDD are suggested.
ISSN:0165-1781
DOI:10.1016/j.psychres.2011.01.021