Thiol/disulfide homeostasis in untreated schizophrenia patients

The aim of the study was to investigate dynamic thiol/disulfide (SH/SS) homeostasis in untreated schizophrenia. Blood thiol/disulfide homeostasis status, which reflects native thiol-disulfide exchanges, was investigated in 87 untreated patients (52 males, 35 females), and the obtained results were c...

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Bibliographic Details
Published in:Psychiatry research 2017-05, Vol.251, p.212-216
Main Authors: Topcuoglu, Canan, Bakirhan, Abdurrahim, Yilmaz, Fatma Meric, Neselioglu, Salim, Erel, Ozcan, Sahiner, Safak Yalcin
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Disulfide
Disulfides - blood
Female
Homeostasis
Humans
Male
Oxidative stress
Schizophrenia
Schizophrenia - blood
Schizophrenia - physiopathology
Sulfhydryl Compounds - blood
Synaptic Transmission - physiology
Thiol
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Summary:The aim of the study was to investigate dynamic thiol/disulfide (SH/SS) homeostasis in untreated schizophrenia. Blood thiol/disulfide homeostasis status, which reflects native thiol-disulfide exchanges, was investigated in 87 untreated patients (52 males, 35 females), and the obtained results were compared with 86 healthy controls. Blood serum native thiol and total thiol (ToSH) concentrations were measured in a paired test. The half value of the difference between native thiol and ToSH concentrations was calculated as the disulfide bond amount. SH and ToSH concentrations were found to be significantly lower (p
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2017.02.016