Results of a phase I study to dose escalate using intensity modulated radiotherapy guided by combined PET/CT imaging with induction chemotherapy for patients with non-small cell lung cancer

Intensity modulated radiation therapy (IMRT) guided by PET/CT imaging with respiratory gating was employed to dose escalate in patients with non-small cell lung cancer (NSCLC), using accelerated fractionation with induction chemotherapies. One patient developed a grade 5 pneumonitis and the study wa...

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Bibliographic Details
Published in:Radiotherapy and oncology 2004-12, Vol.73 (3), p.285-287
Main Authors: Holloway, Caroline L., Robinson, Don, Murray, Brad, Amanie, John, Butts, Charles, Smylie, Michael, Chu, Karen, McEwan, A.J., Halperin, Ross, Roa, Wilson H.
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - radiotherapy
Dose Fractionation
Dose-Response Relationship, Radiation
Female
Humans
Intensity modulation
Lung cancer
Lung Neoplasms - pathology
Lung Neoplasms - radiotherapy
Male
Middle Aged
Normal tissue complication probability
Positron-Emission Tomography
Radiation Pneumonitis
Radiotherapy
Tomography, X-Ray Computed
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Summary:Intensity modulated radiation therapy (IMRT) guided by PET/CT imaging with respiratory gating was employed to dose escalate in patients with non-small cell lung cancer (NSCLC), using accelerated fractionation with induction chemotherapies. One patient developed a grade 5 pneumonitis and the study was halted at 84Gy in 35 fractions.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2004.07.033