Intensity-modulated radiotherapy as the boost or salvage treatment of nasopharyngeal carcinoma: The appropriate parameters in the inverse planning and the effect of patient's anatomic factors on the planning results

The current study demonstrates that the large increase in normal tissue penalty often degrades target dose uniformity without a concomitant large improvement in normal tissue dose, especially in anatomically unfavorable patients. The excessively large normal tissue penalties do not improve treatment...

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Bibliographic Details
Published in:Radiotherapy and oncology 2005-10, Vol.77 (1), p.53-57
Main Authors: Hsiung, Ching-Yeh, Hunt, Margie A., Yorke, Ellen D., Chui, Chen-Shou, Hu, Jason, Xiong, Jian-Ping, Ling, Clifton C., Lo, Sing-Kai, Wang, Chong-Jong, Huang, Eng-Yen, Amols, Howard I.
Format: Article
Language:English
Subjects:
Anatomic factor
Carcinoma - radiotherapy
Dose Fractionation
Dose-Response Relationship, Radiation
Humans
Intensity-modulated radiotherapy
Inverse planning
Nasopharyngeal carcinoma
Nasopharyngeal Neoplasms - radiotherapy
Optimization
Prognosis
Radiation Injuries - etiology
Radiation Injuries - prevention & control
Radiotherapy, Conformal - methods
Salvage Therapy
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Summary:The current study demonstrates that the large increase in normal tissue penalty often degrades target dose uniformity without a concomitant large improvement in normal tissue dose, especially in anatomically unfavorable patients. The excessively large normal tissue penalties do not improve treatment plans for patients having unfavorable geometry.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2005.04.017