Normal tissue complication probability modeling for acute esophagitis in patients treated with conformal radiation therapy for non-small cell lung cancer

To evaluate the ability of a well-known normal tissue complication probability (NTCP) model to predict radiation esophagitis by determining updated model parameters and then comparing these results with the predictive value of other dosimetric parameters. Clinical and dosimetric data regarding esoph...

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Bibliographic Details
Published in:Radiotherapy and oncology 2005-11, Vol.77 (2), p.176-181
Main Authors: Chapet, Olivier, Kong, Feng-Ming, Lee, Julia S., Hayman, James A., Ten Haken, Randall K.
Format: Article
Language:English
Subjects:
Acute Disease
Age Distribution
Aged
Aged, 80 and over
Analysis of Variance
Carcinoma, Non-Small-Cell Lung - epidemiology
Carcinoma, Non-Small-Cell Lung - radiotherapy
Chemotherapy, Adjuvant
Dose Fractionation
Dose-Response Relationship, Radiation
Esophagitis
Esophagitis - epidemiology
Female
Humans
Incidence
Likelihood Functions
Logistic Models
Lung neoplasms
Lung Neoplasms - epidemiology
Lung Neoplasms - radiotherapy
Male
Middle Aged
Models, Statistical
Multivariate Analysis
Neoplasm Staging
NTCP
Parameters
Predictive Value of Tests
Probability
Prognosis
Radiation Injuries - epidemiology
Radiation Injuries - pathology
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Conformal - adverse effects
Radiotherapy, Conformal - statistics & numerical data
Risk Assessment
Severity of Illness Index
Sex Distribution
Survival Analysis
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Description
Summary:To evaluate the ability of a well-known normal tissue complication probability (NTCP) model to predict radiation esophagitis by determining updated model parameters and then comparing these results with the predictive value of other dosimetric parameters. Clinical and dosimetric data regarding esophagitis were analyzed in 101 inoperable/unresectable non-small-cell lung cancer patients treated by external beam irradiation. Grade 2 or higher esophagitis counted as events. Parameters ( TD 50 , n, and m) of the Lyman normal tissue complication probability (NTCP) model were determined using maximum likelihood analysis, and compared to other dose/volume threshold values including: percentage of esophagus receiving >40 Gy (V40) to >75 Gy (V75), and maximum esophageal doses. Sixteen patients developed grade 2–3 acute esophagitis (no G4 or 5). The maximum likelihood analysis produced new Lyman model parameters of: TD 50 =51 Gy, n=0.44 and m=0.32. The mean NTCP value is significantly lower ( P
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2005.10.001