Radiation-induced hypoglossal nerve palsy after definitive radiotherapy for nasopharyngeal carcinoma: Clinical predictors and dose–toxicity relationship

• Published in: Radiotherapy and oncology 2019-09, Vol.138, p.93-98
• Main Authors: Chow, James C.H, Cheung, Ka-Man, Au, Kwok-Hung, Zee, Benny C.Y, Lee, Jack, Ngan, Roger K.C, Lee, Anne W.M, Yiu, Harry H.Y, Li, Kenneth W.S, Leung, Alex K.C, Chan, Jeffrey C.H, Lee, Francis K.H, Wong, Kam-Hung
• Format: Article
• Language: English
• Subjects: Cohort Studies; Female; Hematology, Oncology, and Palliative Medicine; Humans; Hypoglossal nerve; Hypoglossal Nerve Diseases - epidemiology; Hypoglossal Nerve Diseases - etiology; Incidence; Intensity-modulated radiotherapy; Male; Middle Aged; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - radiotherapy; Nasopharyngeal Neoplasms - radiotherapy; Neoplasm Staging; Radiation dosimetry; Radiation Injuries - epidemiology; Radiation Injuries - etiology; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated - adverse effects; Radiotherapy, Intensity-Modulated - statistics & numerical data; Retrospective Studies
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/j.radonc.2019.06.011

Highlights•Radiation-induced hypoglossal (XII) nerve palsy is common in nasopharyngeal carcinoma patients. •Crude incidence was 8.7% (69/797) at a median follow-up of 8.1 years. •Prescribed dose >70 Gy, diabetes, high T-stage and XII canal involvement were independent clinical predictors. •XII nerve D1cc was the best dosimetric predictor for radiation-induced XII nerve palsy (AUC = 0.826). •D1cc